Control of the G-protein cascade dynamics by GDP dissociation inhibitors
نویسندگان
چکیده
منابع مشابه
Control of the G-protein cascade dynamics by GDP dissociation inhibitors.
A network of the Rho family GTPases, which cycle between inactive GDP-bound and active GTP-bound states, controls key cellular processes, including proliferation and migration. Activating and deactivating GTPase transitions are controlled by guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs) and GDP dissociation inhibitors (GDIs) that sequester GTPases from the membra...
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متن کاملGDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein.
The majority of the GTP-binding proteins of the Ras superfamily hydrolyze GTP to GDP very slowly. A notable exception to this are the Rac proteins, which have intrinsic GTPase rates at least 50-fold those of Ras or Rho. A protein (or proteins) capable of inhibiting this GTPase activity exists in human neutrophil cytosol. Since Rac appears to exist normally in neutrophils as a cytosolic protein ...
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ژورنال
عنوان ژورنال: Molecular BioSystems
سال: 2013
ISSN: 1742-206X,1742-2051
DOI: 10.1039/c3mb70152b